Yuyan Instrument can provide various styles of oral and nasal inhalation exposure systems to meet the oral and nasal exposure needs of different experimental animals, such as mice, rats, rabbits, dogs, monkeys, etc.

The equipment has excellent workmanship, high air tightness, and is equipped with a circulation ventilation function to promote timely emission of exhaust gas. It can be paired with an integrated inhalation exposure experimental cabinet to reduce the harm to experimental personnel. The digital control system also has detection and control functions.

From small-scale inhalation efficacy trials to large-scale inhalation toxicity evaluations, we can provide you with mature and reliable system solutions, technical support, and validation services.

Oral and nasal inhalation exposure systemMain features:

·Exposure is rapid, concentration is uniform, and exposure concentration can be reached in a short period of time

·Only through the nasal breathing of animals can they come into contact with the tested substance, effectively preventing the skin and mouth of animals from coming into contact with the tested substance

·Real time monitoring of animal respiratory rate and inhalation volume by detecting chest expansion movements

·Adopting a double-layer tower structure design to ensure uniform concentration of sample inhalation

·At the same time, it is easy to regulate the concentration of the sample, respond quickly to changes in concentration, and has a small dead volume, which can achieve concentration equilibrium in a short period of time

·Suitable configurations can be selected according to needs, and 6-24 experimental animals can be exposed at once

·There are fixators suitable for animals of different weights to choose from

·The flow direction of aerosols can be reversed

·Multiple specifications of aerosol generators and dust generators are available for selection

·Additive particle monitoring device

·Flexible configuration, easy expansion, and convenient disassembly and assembly

·Reasonable pipeline and gas path design, good sealing, and no external leakage

·The exhaust gas is filtered through multiple stages, which can effectively avoid pollution

·Using anti-corrosion materials, smooth and flat, without dead corners, easy to clean

model: IES 324

model: S2008R

Main structure and features of the mouth and nose exposure towerThrowing surface diagram：

Compact structure, rapid response to concentration changes, and small dead volume, capable of achieving concentration equilibrium in a short period of time;

Adopting a double-layer tower structure design, each animal's breathing passes through different respiratory pathways, and the aerosol concentration that each animal is exposed to is consistent;

Expose the unidirectional flow of aerosols inside the tower to ensure that the aerosols in contact with each animal are not affected by other animals;

Different models of mouth exposed towers:Single layer, double layer, four layer

Select the appropriate model based on the number of animals: 6 channels per layer. Three models can be used for exposure experiments on 6, 12, and 24 mice, respectively.

Suitable fixators for rats and mice of different weights:

Animal respirationjoinNumerical measurement system

According to the needs, a respiratory parameter measurement system can be selected to detect and statistically analyze various respiratory parameters of animals;

Measurement parameters: aerosol accumulation, respiratory rate, peak expiratory value, peak inspiratory value, expiratory time, inspiratory time, maximum expiratory flow rate, maximum inspiratory flow rate, tidal volume, end expiratory pause, end inspiratory pause, minute respiratory volume, etc

Construction diagram of the respiratory parameter measurement system after assembly:

Respiratory parameter measurement software interface:

aerosol generator

Aerosol atomizer is an important component of oral and nasal exposure. When used in conjunction with an exposure tower, it pushes the atomized aerosol into the exposure chamber and continuously atomizes and maintains a certain aerosol concentration inside the exposure chamber.

Can be used with Aerogen Pro atomizer and Aerogen Solo atomizer;

The atomizer adopts palladium alloy vibrating grid technology, with a central orifice plate diameter of 5mm and 1000 precision formed micropores evenly distributed. It vibrates 128000 times per second, forming aerosol particle droplets that are very conducive to sedimentation into the lungs.

model: Aerogen Pro

Main advantages of the product:

·Both short-term and long-term experiments can ensure excellent and consistent output;
·Low atomization dose;
·The particle size distribution and particle object concentration have a high degree of repeatability;
·Medication can be filled at any time, and an automatic injection pump can also be used to add medication;
·Corrosion resistant shell design, durable and long-lasting;
·Highly integrated and compact in size;
·Easy to operate, no need for complex training work;

Main parameters of atomizing head：
·Small: Volume Median Diameter(VMD)
·Atomization rate:> 0.1mL/min
·Particle size: VMD (volume median diameter) ranging from 2.5 μ m to 4.0 μ m
·Drug residual amount:< 0.1mL

·Liquid atomized aerosols have many applications in scientific research, drug development, and quality testing;

Schematic diagram of atomizer connection:

Particle size distribution of atomized particles:

According to your needs, you can also choose Collison style aerosol generators

MRE Collison aerosol generator is a flat bottom spray designed by Microbiological Research Establishment, which adopts the stamping atomization principle. It has a variety of models including 1 nozzle, 3 nozzles and 6 nozzles. 3 nozzles are the most commonly used model.

If full body nebulization is required, the following options can be selected:Full body exposure box

The whole body exposure system can atomize drugs, allergens, or other mixtures into extremely fine air soluble suspended particles and deliver them into a box placed in an animal. The animal is exposed to it for the predetermined experimental time to complete the sensitization and stimulation process required for animal modeling; It can also be used as a whole body exposure system to expose animals to the whole body;

(Yuyan Instrument Company can customize special gas poisoning boxes according to customer needs, such as carbon dioxide control boxes, sulfur dioxide poisoning boxes, carbon monoxide poisoning boxes, oxygen concentration control boxes, etc. Welcome to inquire by phone)

There are various sizes and specifications of exposed boxes to choose from, and customization can also be made according to needs:

Note: The actual capacity may vary depending on the age and weight of the animals. According to the characteristics of the drug, nebulization and exposure devices are best used in biosafety cabinets.

Exposure box model: S2

The main characteristics of the whole-body exposure system are:

·Simultaneously modeling multiple animals saves time and has good consistency.

·According to relevant literature, taking OVA sensitization as an example, modeling with nebulization method requires less time than abdominal injection method.

·The integrated controller also has timer function, atomization parameter setting, and 0-5LPM bias air supply system.

·Biased air supply can provide fresh air for animals inside the box during a prolonged sensitization process, while maintaining the temperature and humidity inside the box from being too high.

·We offer two types of atomizing heads with particle diameters of 2.5-4 μ m and 4-6 μ m for selection.

The following image shows the animals exposed to the Collison aerosol generator with an animal poisoning chamber and compression pump

The specifications and dimensions of animal poisoning boxes can be customized according to customer needs:

According to the experimental requirements, you may need a dust generator, aerosol generator, particle concentration meter, and aerosol concentration meter:

Dust particle generator

Particle concentration measuring instrument, used for real-time measurement of particle concentration in exposed environments

Aerosol concentration measuring instrument, used for real-time measurement of aerosol concentration in exposed environments

Partial application literature:
[1] Zhang Yuanyuan, Zhang Hao, Geng Xiwen, etc Experimental study on the anti anxiety and hypnotic effects of oral and nasal inhalation administration of agarwood tablets in mice [J]. Journal of Shandong University of Traditional Chinese Medicine, 2021, 45(1):7.
[1] Dai He Application Research of Oral and Nasal Inhalation Exposure System [D]. Shanghai Jiao Tong University, 2018 DOI: 10.27307/d.cnki.gsjtu.2018.004971
[2] Hao Xinyan, Zhang Yuanhui, Gao Hong Characteristics and Applications of Animal Aerosol Exposure Devices [J]. Chinese Medical Equipment, 2018, 15 (01): 127-130
[3] Hao Xinyan Application and evaluation of animal nasal aerosol exposure device in animal models of pathogen infection [D]. Peking Union Medical College, 2019 DOI: 10.27648/d.cnki.gzxhu.2019.000548
[4] Wang Ying The effects of bisphenol A exposure during pregnancy and lactation on hippocampal function in neonatal rats [D]. China Medical University, 2021. DOI: 10.27652/d.cnki.gzyku.2021.000130
[5] Ji Xiaotong PM_ (2.5) inhalation exposure induces lung injury and its molecular mechanism [D]. Shanxi University, 2019
[6] Ku Tingting Study on neurotoxicity induced by PM_ (2.5) exposure and its related molecular mechanisms [D]. Shanxi University, 2017
[7] Ma Yongchang Study on the effect and mechanism of ROS scavenging nanoparticles in the treatment of neutrophil asthma [D]. PLA Army Military Medical University, 2021. DOI: 10.27001/d.cnki.gtjyu.2021.000097

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